Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei
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چکیده
منابع مشابه
Selenium and the methionine sulfoxide reductase system.
Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, resp...
متن کاملMethionine sulfoxide reductase A is a stereospecific methionine oxidase.
Methionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methionine. Because oxidation of methionine residues is reversible, this covalent modification could also functio...
متن کاملRole of Helicobacter pylori methionine sulfoxide reductase in urease maturation.
The persistence of the gastric pathogen Helicobacter pylori is due in part to urease and Msr (methionine sulfoxide reductase). Upon exposure to relatively mild (21% partial pressure of O2) oxidative stress, a Δmsr mutant showed both decreased urease specific activity in cell-free extracts and decreased nickel associated with the partially purified urease fraction as compared with the parent str...
متن کاملMethionine Sulfoxide Reductase System in Health and Disease
cell cultures has been shown to protect these cells from enhanced MetO accumulations while increasing their survival rates under oxidative stress conditions [24]. In addition, several compounds have demonstrated an ability to induce Msr activity in neuronal cell cultures [25]. This observation supports the identification and development of novel compounds that may serve as therapy treatments ag...
متن کاملMethionine sulfoxide reduction and assimilation in Escherichia coli: new role for the biotin sulfoxide reductase BisC.
Methionine ranks among the amino acids most sensitive to oxidation, which converts it to a racemic mixture of methionine-S-sulfoxide (Met-S-SO) and methionine-R-sulfoxide (Met-R-SO). The methionine sulfoxide reductases MsrA and MsrB reduce free and protein-bound MetSO, MsrA being specific for Met-S-SO and MsrB for Met-R-SO. In the present study, we report that an Escherichia coli metB1 auxotrop...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2017
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2017.08.023